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 Post subject: CQ10
PostPosted: Thu Mar 13, 2008 9:54 pm 
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Does anyone know anything about it or has seen any legitimate research on it?


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PostPosted: Fri Mar 14, 2008 11:07 am 
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Its a vitamin like substance which people supplement due to possible health benefits. Antioxidant, aids with weight loss, heart health, etc.


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PostPosted: Fri Mar 14, 2008 11:44 am 
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That's what the adds say. I haven't seen any research on it, yet.


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PostPosted: Fri Mar 14, 2008 12:17 pm 
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If I find anything on it i'll send the info over.


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PostPosted: Fri Mar 14, 2008 2:24 pm 
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Thanks.


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PostPosted: Mon Mar 17, 2008 11:50 am 
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Overview
Coenzyme Q10 (CoQ10) is a compound found naturally in the energy-producing center of the cell known as the mitochondria. CoQ10 is involved in the making of an important molecule known as ATP. ATP serves as the cell's major energy source and drives a number of biological processes including muscle contraction and the production of protein. CoQ10 also works as an antioxidant.

Antioxidants are substances that scavenge free radicals, damaging compounds in the body that alter cell membranes, tamper with DNA, and even cause cell death. Free radicals occur naturally in the body, but environmental toxins (including ultraviolet light, radiation, cigarette smoking, and air pollution) can also increase the number of these damaging particles. Free radicals are believed to contribute to the aging process as well as the development of a number of health problems including heart disease and cancer. Antioxidants such as CoQ10 can neutralize free radicals and may reduce or even help prevent some of the damage they cause.



Uses
CoQ10 boosts energy, enhances the immune system, and acts as an antioxidant. A growing body of research suggests that using coenzyme Q10 supplements alone or in combination with other drug therapies and nutritional supplements may help prevent or treat some of the following conditions:

Heart Disease

Researchers believe that the beneficial effect of CoQ10 in the prevention and treatment of heart disease is due to its ability to improve energy production in cells, inhibit blood clot formation, and act as an antioxidant. One important study, for example, found that people who received daily CoQ10 supplements within 3 days of a heart attack were significantly less likely to experience subsequent heart attacks and chest pain. In addition, these same patients were less likely to die of heart disease than those who did not receive the supplements.

Congestive Heart Failure (CHF)

Levels of CoQ10 are low in people with CHF, a debilitating disease that occurs when the heart is not able to pump blood effectively. This can cause blood to pool in parts of the body such as the lungs and legs. Information from many research studies suggests that CoQ10 supplements help reduce swelling in the legs, enhance breathing by reducing fluid in the lungs, and increase exercise capacity in people with CHF. Not all studies agree, however. As a result, some experts conclude that CoQ10 supplements do not contribute any benefit to the usual conventional treatment for CHF. More conclusive research will help resolve the debate.

High Blood Pressure

Several studies involving small numbers of people suggest that CoQ10 may lower blood pressure. However, it may take 4 to 12 weeks before any beneficial effect is observed. More research with greater numbers of people is needed to assess the value of CoQ10 in the treatment of high blood pressure.

High Cholesterol

Levels of CoQ10 tend to be lower in people with high cholesterol compared to healthy individuals of the same age. In addition, certain cholesterol-lowering drugs called statins (such as atorvastatin, cerivastatin, lovastatin, pravastatin, simvastatin) appear to deplete natural levels of CoQ10 in the body. Taking CoQ10 supplements can correct the deficiency caused by statin medications without affecting the medication's positive effects on cholesterol levels.

Diabetes

CoQ10 supplements may improve heart health and blood sugar and help manage high cholesterol and high blood pressure in individuals with diabetes. (High blood pressure, high cholesterol, and heart disease are all common problems associated with diabetes). Despite some concern that CoQ10 may cause a sudden and dramatic drop in blood sugar (called hypoglycemia), two recent studies of people with diabetes given CoQ10 two times per day showed no hypoglycemic response. The safest bet if you have diabetes is to talk to your doctor or registered dietitian about the possible use of CoQ10.

Heart Damage caused by Chemotherapy

Several studies suggest that CoQ10 may help prevent heart damage caused by certain chemotherapy drugs (namely adriamycin or other athracycline medications). More scientific studies are needed to further evaluate the effectiveness of CoQ10 in preventing heart damage in cancer patients undergoing chemotherapy.

Heart Surgery

Research indicates that introducing CoQ10 prior to heart surgery, including bypass surgery and heart transplantation, can reduce damage caused by free radicals, strengthen heart function, and lower the incidence of irregular heart beat (arrhythmias) during the recovery phase.

Breast Cancer

Studies of women with breast cancer suggest that CoQ10 supplements (in addition to conventional treatment and a nutritional regimen including other antioxidants and essential fatty acids) may shrink tumors, reduce pain associated with the condition, and cause partial remission in some individuals. It is important to recognize that the beneficial effects these women experienced cannot be attributed to CoQ10 alone. Additional antioxidants used in these studies include vitamins C, E, and selenium.

Periodontal (gum) Disease

Gum disease is a widespread problem that is associated with swelling, bleeding, pain, and redness of the gums. Studies have shown that people with gum disease tend to have low levels of CoQ10 in their gums. In a few studies involving small numbers of subjects, CoQ10 supplements caused faster healing and tissue repair. Additional studies are needed to evaluate the effectiveness of CoQ10 when used together with traditional therapy for periodontal disease.

Other

Preliminary studies also suggest that CoQ10 may:

Improve immune function in individuals with immune deficiencies (such as AIDS) and chronic infections (such as yeast and other viral infections)
Increase sperm motility leading to enhanced fertility
Be used as part of the treatment for Alzheimer's disease
Reduce damage from stroke
Boost athletic performance
Enhance physical activity in people with fatigue syndromes
Improve exercise tolerance in individuals with muscular dystrophy
Research in all of these areas is underway to determine whether CoQ10 can be safety and effectively used in people with these health problems.



Dietary Sources
Primary dietary sources of CoQ10 include oily fish, organ meats such as liver, and whole grains. Most individuals obtain sufficient amounts of CoQ10 through a balanced diet, but supplementation may be useful for individuals with particular health conditions (see Uses section) or those taking certain medications (see Interactions section).



Available Forms
Coenzyme Q10 is available as a supplement in several forms, including softgel capsules, oral spray, hardshell capsules, and tablets.



How to Take It
Pediatric

There are no known scientific reports on the pediatric use of CoQ10. Therefore, use of CoQ10 supplements is not currently recommended for children.

Adult

The general recommended dose for CoQ10 supplementation is 30 to 60 mg daily. Higher doses have been used in studies and may be recommended for the following conditions:

Congestive heart failure: 50 to 150 mg a day
High blood pressure: 50 to 150 mg a day
To enhance athletic performance: 60 mg a day for 4 to 8 weeks
Heart attack: 120 mg a day for 28 days after the heart attack
Breast cancer: 400 mg per day for potential prevention and treatment
Coenzyme Q10 is fat-soluble so should be taken with a meal containing fat for optimal absorption.



Precautions
Because of the potential for side effects and interactions with medications, dietary supplements should be taken only under the supervision of a knowledgeable healthcare provider.

Coenzyme Q10 appears to be generally safe with no significant side effects, except occasional stomach upset. However, the safety of CoQ10 supplementation during pregnancy and breastfeeding is unknown and, therefore, should not be used during that time until more information is available.



Possible Interactions
If you are currently being treated with any of the following medications, you should not use CoQ10 without first talking to your healthcare provider.

Daunorubicin and Doxorubicin
Coenzyme Q10 may help to reduce the toxic effects on the heart caused by daunorubicin and doxorubicin, two chemotherapy medications that are commonly used to treat a variety of cancers.

Blood Pressure Medications
In a study of individuals taking blood pressure medications (including diltiazem, metoprolol, enalapril, and nitrate), CoQ10 supplementation allowed the individuals to take lower dosages of these drugs. This suggests that CoQ10 may enhance the effectiveness of certain blood pressure medications, but more research is needed to verify these results.

Warfarin
There have been reports that coenzyme Q10 may decrease the effectiveness of blood-thinning medications such as warfarin, leading to the need for increased doses. Therefore, given that this medication must be monitored very closely for maintenance of appropriate levels and steady blood thinning, CoQ10 should only be used with warfarin under careful supervision by your healthcare provider.

Timolol
CoQ10 supplementation may reduce the heart-related side effects of timolol drops, a beta-blocker medication used to treat glaucoma, without decreasing the effectiveness of the medication.

Other
Medications that can lower the levels of coenzyme Q10 in the body include statins for cholesterol (atorvastatin, cerivastatin, lovastatin, pravastatin, simvastatin), fibric acid derivatives for cholesterol (specifically, gemfibrozil), beta-blockers for high blood pressure (such as atenolol, labetolol, metoprolol, and propranolol), and tricyclic antidepressant medications (including amitriptyline, amoxapine, clomipramine, desipramine, doxepin, imipramine, nortriptyline, protriptyline, and trimipramine).



Supporting Research
Aberg F, Appelkvist EL, Broijersen A, et al. Gemfibrozil-induced decrease in serum ubiquinone and alpha- and gamma-tocopherol levels in men with combined hyperlipidaemia. Eur J Clin Invest . 1998;28:235-242.

Al-Hasso. Coenzyme Q10: a review. Hosp Pharm . 2001;36(1):51-66.

Alleva R, Scaraarmucci A, Mantera F, Bompandre S, Leoni L, Linarro GP. The protective role of ubiquinol—10 against formation of lipid hydroperoxdes in human seminal fluids. Mol Asp Med . 1997;18:221-228.

Baggio E, Gandini R, Plancher AC, Passeri M, Carmosino G. Italian multicenter study on the safety and efficacy of coenzyme Q10 as adjunctive therapy in heart failure. CoQ10 Drug Surveillance Investigators. Mol Aspects Med . 1994;15(Suppl):s287-294.

Chello M, Mastroroberto P, Romano R, et al. Protection by coenzyme Q10 from myocardial reperfusion injury during coronary artery bypass grafting. Ann Thorac Surg . 1994;58(5):1427-1432.

Chopra RK, Goldman R, Sinatra ST, Bhagavan HN. Relative bioavailability of coenzyme Q10 formulations in human subjects. Int J Vitam Nutr Res . 1998;68:109-113.

de Bustos F, Molina JA, Jimenez-Jimenz FJ, Garcia-Redondo A, Gomez-Escalonilla C, Porta-Etessam J, et al. Serum levels of coenzyme Q10 in patients with Alzheimer's disease. J Neural Transm . 2000;107(2):233-239.

Eriksson JG. The effects of coenzyme Q10 administration on metabolic control in patients with type 2 diabetes mellitus. Biofactors . 1999;9(2-4):315-318.

Folkers K, Langsjoen P, Nara Y, et al. Biochemical deficiencies of coenzyme Q10 in HIV infection and exploratory treatment. Biochem Biophys Res Commun . 1988;153:888-896.

Hanioka T, Tanaka M, Ojima M, Shizukuishi S, Folkers K. Effect of topical application of coenzyme Q10 on adult periodontitis. Mol Aspects Med. 1994;15 Suppl:s241-248.

Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health-System Pharm . 2000;57(13):1221-1227.

Henriksen J, Andersen CB, Hother-Nielsen O, Vaag A, Mortensen SA, Beck-Nielsen H. Impact of ubiquinone (coenzyme Q10) treatment on glycaemic control, insulin requirement and well-being in patients with type 1 diabetes mellitus. Diabet Med . 1999; 16:312-8.

Human JA, Ubbink JB, Jerling JJ, et al. The effect of simvastatin on the plasma antioxidant concentrations in patients with hypercholesterolemia. Clin Chim Acta . 1997;263(1):67-77.

Iarussi D, Auricchio U, Agretto A, et al. Protective effect of coenzyme Q on anthracylines cardiotoxicity: control study in children with acute lymphoblastic leukemia and non-hodgkin lymphoma. Molec Aspects Med . 1994;15(Suppl):S207-S212.

Jolliet P, Simon N, Barre J, et al. Plasma coenzyme Q10 concentrations in breast cancer: prognosis and therapeutic consequences. Int J Clin Pharmacol Ther . 1998;36:506-509.

Judy WV, Hall JH, Dugan W, et al. Coenzyme Q10 reduction of adriamycin cardiotoxicity. In: Folkes K, Yamamura Y, Eds. Biomedical and clinical aspects of coenzyme Q10 , Vol. 4. Amsterdam: Elsevier. 1984:231-241.

Kendler BS. Recent nutritional approaches to prevention and therpy of cardiovascular disease. Prog Cardiovasc Nurs . 1997;12(3):3-23.

Khatta M, Alexander BS, Krichten CM, Fisher ML, Freudenberger R, Robinson SW et al. The effect of conenzyme Q10 in patients with congestive heart failure. Ann Int Med . 2000;132(8):636-640.

Landbo C, Almdal TP. Drug interaction between warfarin and coenzyme Q10. Ugeskrift for Laeger . 1998;160(22):3226-3227.

Langsjoen P, Langsjoen A. Overview of the use of CoQ10 in cardiovascular disease. BioFactors . 1999;9:273-284.

Langsjoen P, Langsjoen A, Willis R, Folkers K. Treatment of Essential Hypertension with Coenzyme Q10. Molec Aspects Med . 1994;15:s265-s272.

Lewin A, Loron M. The effect of coenzyme Q10 on sperm mobility and function. Mol Asp Med . 1997;18:213-219.

Lockwood K, Moesgaard S, Folkers K. Partial and complete regression of breast cancer in patients in relation to dosage of coenzyme Q10. Biochem Biophys Res Commun . 1994;199(3):1504-1508.

Lockwood K, Moesgaard S, Hanioka T, Folkers K. Apparent partial remission of breast cancer in "high risk" patients supplemented with nutritional antioxidants, essential fatty acids, and coenzyme Q10. Mol AspMed . 1994;15 Suppl:s231-s240.

Lockwood K, Moesgaard S, Yamamoto T, Folkers K. Progress in therapy of breast cancer with vitamin Q10 and the regression of metastases. Biochem Biophys Res Commun. 1995;212(1):172-177.

Marz W, Wieland H. HMG-CoA reducatse inhibition: anti-inflammatory effects beyond lipid lowering. Herz . 2000;25(6):117-25.

Matthews RT, Yang L, Browne S, Baik M, Beal MF. Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects. Proc Natl Acad Sci USA. July 21, 1998; 95:8892-8897.

McCarty MF. Coenzyme Q versus hypertension: does CoQ decrease endothelial superoxide generation? Med Hypotheses. 1999;53:300-304.

McCarty MF. Toward practical prevention of type 2 diabetes. Med Hypotheses. 2000;54(5):786-793.

Miyake Y, Shouza A, Nishikawa M, Yonemoto T, Shimizu H, Omoto S, Hayakawa T, Inada M. Effect of treatment with 3-hydroxy-3methylglutaryl coenzyme A reductase inhibitors on serum coenzyme Q10 in diabetic patients. Arzneimittelforschung . 1999;49(4):324-329.

Mortensen SA, Leth A, Agner E, Rohde M. Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors. Mol Aspects Med . 1997;18Suppl:S137-S144.

Musumeci O, Naini A, Slonim AE, Skavin N, Hadjigeorgiou GL, Krawiecki N, et al. Familial cerebellar ataxia with muscle coenzyme Q10 deficiency. Neurol . 2001;56(7):849-855.

Niibori K, Yokoyama H, Crestanello JA, Whitman GJ. Acute administration of liposomal coenzyme Q10 increases myocardial tissue levels and improves tolerance to ischemia reperfusion injury. J Surg Res . 1998;79:141-145.

Ostrowski RP. Effect of coenzyme Q(10) on biochemical and morphological changes in experimental ischemia in the rat brain. Brain Res Bull . 2000;53(4):399-407.

Ott BR, Owens NJ. Complementary and alternative medicines for Alzheimer's disease. J Geriatr Psychiatry Neurol . 1998;11:163-173.

Overvad K, Diamant B, Holm L, Holmer G, Mortensen SA, Stender S. Review coenzyme Q10 in health and disease. Eur J Clin Nut . 1999;53:764-770.

Raitakari OT, McCredie RJ, Witting P, Griffiths KA, Letter J, Sullivan D, Stocker R, Celermajer DS. Coenzyme Q improves LDL resistance to ex vivo oxidation but does not enhance endothelial function in hypercholesterolemic young adults. Free Radic Biol Med . 2000;28(7):1100-1105.

Serebruany VL, Ordonez JV, Herzog WR, et al. Dietary coenzyme Q10 supplementation alters platelet size and inhibits human vitronectin (CD51/CD61) receptor expression . J Cardiovasc Pharmacol. 1997;29:16-22.

Shils ME, Olson JA, Shike M, Ross AC. Modern Nutrition in Health and Disease . 9th ed. Baltimore, Md: Williams & Wilkins; 1999:90-92: 1377-1378.

Shinozawa S, Kawasaki H, Gomita Y. [Effect of biological membrane stabilizing drugs (coenzyme Q10, dextran sulfate and reduced glutathione) on adriamycin (doxorubicin)-induced toxicity and microsomal lipid peroxidation in mice]. Gan To Kagaku Ryoho . 1996;23(1):93-98.

Sinclair S. Male infertility: nutritional and environmental considerations. Alt Med Rev . 2000;5(1):28-37.

Singh RB, Niaz MA, Rastogi SS, Shukla PK, Thakur AS. Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease. J Hum Hypertens . 1999;13(3):203-208.

Singh RB, Wander GS, Rastogi A, et al. Randomized, double-blind placebo-controlled trial of coenzyme Q10 in patients with acute myocardial infarction. Cardiovasc Drugs Ther. 1998;12:347-353.

Spigset O. Reduced effect of warfarin caused by ubidecarenone. Lancet . 1994;344:1372-1373.

Takahashi N, Iwasaka T, Sugiura T, et al. Effect of coenzyme Q10 on hemodynamic response to ocular timolol. J Cardiovasc Pharmacol . 1989;14:462-468.

Torkos S. Drug-nutrient interactions: A focus on cholesterol-lowering agents. Int J Integrative Med . 2000;2(3):9-13.

Tsukahara Y, Wakatsuki A, Okatani Y. Antioxidant role of endogenaous coenzyme Q against the iscemic and reperfusion-induced lipid peroxidation in fetal rat brain. Acta Obstet Gynecol Scand . 1999;78(8):669-674.

Werbach M. Foundations of Nutritional Medicine . Tarzana, Calif: Third Line Press, Inc.; 1997:209.

Wilkinson EG, Arnold RM, Folkers K. Treatment of periodontal and other soft tissue diseases in the oral cavity with coenzyme Q10. In: Folker K, Yamamura Y, eds. Biomedical and Clinical Aspects of Coenzyme Q10 , Vol 1. Elsevier/North-Holland Biomedical Press;Amsterdam, 1977:251-265.

Witte KK, Clark AL, Cleland JG. Chronic heart failure and micronutrients. J Am Coll Cardiol . 2001;37(7):1765-1774.

Zhou Q, Chan E. Accuracy of repeated blood sampling in rats: A new technique applied in pharmacokinetic/pharmacodynamic studies of the interaction between warfarin and Co-enzyme Q10. J Pharmacol Toxicol Methods . 1998;40(4):191-199.


Theres your sources and info.


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 Post subject:
PostPosted: Tue Mar 18, 2008 9:57 am 
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That is what I couldn't find. Thanks.


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