Mark, that's a tricky subject, and you will get various answers. I don't think there is any "perfect" set/reps ratio. However, there are some general guidelines that you can use based on loading intensities, etc. For 12 reps and up, intensities at 65% or below, 1-2 sets depending on if there are a lot of other exerises thrown into the mix , for 8-12 reps, around 65-75 %, same criteria, 2-4 sets, for the 4-8 rep range, usually around 3-5 sets. For strength/neural in the 1-4 rep ranges, generally 5 or more sets. Of course the higher number of reps and the lower the intensities, the shorter the rest breaks (no major inroads into CNS recovery), and vice versa as the reps get lower. Again, these are generalizations. Google Charles Poliquin, Ian King, as they have written good articles on the relationships of rest/sets/reps. Also, at drsquat.com , in the articles section, it is discussed there. Just remember, nothing is really written in stone.