Wouldn't drop sets fall into this same category? There is the sudden loss of tension when changing the weight and momentarily racking the weight. (especially if you don't have two bro's doing the job for you).Inter-Repetition Rest
It appears that any rest between repetitions "Reset" the muscle firing sequence.
Back To Square One
If you have progressed to innervating the Type IIB/X Muscle Fiber in a movement, pausing to rest take the Type IIB/X out of the equation.
It appears that the pause basically take you back to eliciting Type I Muscle Fiber and then having to work you way back up to Type IIA and then IIB/X.
With that information in mind, a Drop Set would definitely mean you end up starting all over again with Type I Muscle Fiber and working your back up.