Supplement Questions


I am in my mid 40s and have not been seeing much progress in the gym. Someone suggested I should consider using MGF . I looked up "MGF supplement" on Google and found alot of information. Please let me know what you think of it.

Dr. Eric Serrano, MD found no significant increase of growth hormone with MGF spray in his clinical studies. Dr. Serrano has noted a significant increase of growth hormone with 8 to 12 grams of arginine pyroglutamate, but he warns some people get nauseated.

Amino acids, such as Arginine and Orthinine may increase growth hormone, but it has been proposed a stress to the body, such as irritation to the gastrointestinal system can increase growth hormone. Interestingly, workouts with only a brief rest between sets and exercises can increase growth hormone.

The effects of growth hormone in adults seem to be more lipolytic than anabolic. In other words, an increase of growth hormone may burn fat more than build muscle.


Would you recommend 1-AD (Androgen-1). It contains 1 (5-alpha) Androstene 3, 17 diol 100mg. The label says: "The Anabolic platform from IDS is made up of prohormones which primarily effect muscle tissue similar to Deca Durabolin, Anavar, or Primabolin."

Dr Eric Seranno, MD, explains this prohormone is a very active compound, and even though Androstene supposedly does not metabolize to estrogen directly, it will affect estrogen receptors. He suggests you would be better off spending your money on steroids and get better results with the same side effects. Dr. Serrano explains:

"In my clinic, 90% of the people that use prohormones for a long time will get some type of mental problem, depression, anxiety, something, that is why I don't recommend t hem".

Serrano feels the manufacturers and resellers of these supplements have been less than honest toward consumers about how well these compounds work. He does see results with some of his patients within 6 weeks, increasing in size and strength, but after, there is no additional progress. Serrano suggests if someone insists on using prohormones, they consider using them 6 weeks on and three weeks off.

Dr Mauro Di Pasquale, MD also points out problems with the use of prohormone:

  • Any increase in androgen / testosterone formation decreases testicular steroidogenesis
    • possible lower testosterone levels as HPTA becomes refractory
  • Estrogen and DHT formation
  • Potential adverse effects
  • Positive drug test

Dr. Di Pasquale concludes:

"Prohormones are too big of market to let go. We will see many variations of them in the future."

Update: The US Government has recently enacted law prohibiting the sale of prohormones supplements.

Myostatin Suppression Supplement

Do you know anything or have any research about this supplement that supposedly suppresses myostatin?

Joshua Seedman replies:

The general consensus seems to be that myostatin expression in the body is so genetic that no form of supplementation currently available can alter the genetic state. There are specific companies out there that are trying to market myostatin inhibitors and blockers but so far there seems to be no real evidence to prove that they work. It's kind of funny because as soon as studies came out about Myostatin and how there was a lack of this gene in certain animals like the Belgian Blue Cow and certain whippet dogs everyone started jumping on the bandwagon thinking that a supplement could easily be made to replicate the same effects as in these rare creatures. It also appears that there were a few children born within the last several years who have the genetic makeup lacking the myostatin gene. It sounds like even at an early age they are already very muscular and have extreme potential for muscle growth. There is also a theory out there that certain bodybuilders such as Ronnie Coleman have this specific gene as well.

However, there is a certain company called Wyeth that has been working on Myostatin inhibitors and blockers since the late 90s. They had been specifically working on a drug called MYO-029 that had high hopes of blocking myostatin in certain patients with muscular dystrophy. They also thought that if it worked on patients with this disease it could possibly transfer into the athletic setting. However, in the beginning of 2008 they called it quits on this specific drug due to the fact that studies were not showing any results from its use. I guess they are still working on blocking myostatin or limiting its expression but they are starting from scratch with a new formula.

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