I don't see any glaring red flags on the list. None of the meds are necessarily bad.
I wouldn't stop more than one at a time. I'll mention which can or should not be stopped without tapering. If you stop a med, and the target symptoms get worse, well, then you know it's been helping. If your wife is no worse off without it, leave it off. Give it a couple of weeks before stopping another.
One thing to clarify is your use of the word "coeliac". I suspect there is a difference in the British and the American use of the term. The literal meaning is "of or relating to the abdominal cavity." We use it as short-hand of "celiac spru" which is a condition of sensitivity to gluten. A couple of the meds you use it with are laxitives, but a couple are not used as such commonly in the US. On your side of the pond, does "coeliac" mean the same as "laxitive" on ours?
Don't know the brand name, but it sounds like diclofenac, one of the older anti-inflammatories. No one anti-inflammatory is necessarily any better than the others, but sometimes a particular one will work better for a person than another. If it's working well, leave it alone. Side effects are usually apparent, so if she's not having problems, leave it alone. If it's not working, ask to try a different one. If she's not sure if it's working or not, stop it for a couple of weeks. If she doesn't get any worse, it wasn't working very well. If she does get worse, then start it up again. No need to taper.Rik-Blades wrote:Dicloflex 50mg-one, three times a day (anti-inflammatory)
Stimulant laxative. Can lose effectiveness over time. No problem with stopping to see what happens. I wonder about two different stimulants at once.Rik-Blades wrote:Bisacodyl 5mg-one in the Morning-two in the Evening (Coeliac)
Also used for chronic pain. Common side effects are dry mouth, sedation (which may be a good thing in some cases), can cause a little constipation. 100mg is a small dose. If it's working, and no side effects, I'd leave it alone. Otherwise, there are a number of newer meds that are very effective for OCD. OCD can be disabling, so this may be a much-needed med. If she stops it, she should taper. 50 mg for a week, 1/2 tab for a week, then off. Re-starting, reverse the order of the doses.Rik-Blades wrote:Clomipramine 50mg-two at Night (OCD)
I know this med well, use it a lot for various GI problems, but not very often for constipation. Very low in side effects. No need to taper.Rik-Blades wrote:Metoclopramide 10mg-one, three times a day (Coeliac)
Another stimulant laxative. Same as above.Rik-Blades wrote:Senna 7.5mg-three in the Morning three in the Evening (Coeliac)
Often used in the US in over-the-counter products for gasiness. A pretty mild product. No need to taper.Rik-Blades wrote:Simeticone 100mg-one, three times a day (Coeliac)
I don't know this med, at least not under this name. Sorry.Rik-Blades wrote:Zamadol 50mg-two, three times a day (Pain)
In the laxatives, good possibilities are lactulose, polyethylene glycol and sorbitol. Just ideas. They are not expensive in the US, so they maybe on the formulary in the NHS.
I hope this helps.