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Inflamation/IGF-1 For Wound Healing

Posted: Sat Feb 26, 2011 10:01 am
by Kenny Croxdale
Interesting stuff on inflamation and wound healing.

Kenny Croxdale ... 100410.php

Federation of American Societies for Experimental Biology

Surprise: Scientists discover that inflammation helps to heal wounds New research in the FASEB Journal suggests that muscle inflammation after acute muscle injury is essential to muscle repair by means of insulin-like growth factor-1

A new research study published in The FASEB Journal ( may change how sports injuries involving muscle tissue are treated, as well as how much patient monitoring is necessary when potent anti-inflammatory drugs are prescribed for a long time. That's because the study shows for the first time that inflammation actually helps to heal damaged muscle tissue, turning conventional wisdom on its head that inflammation must be largely controlled to encourage healing. These findings could lead to new therapies for acute muscle injuries caused by trauma, chemicals, infections, freeze damage, and exposure to medications which cause muscle damage as a side effect. In addition, these findings suggest that existing and future therapies used to combat inflammation should be closely examined to ensure that the benefits of inflammation are not eliminated.

"We hope that our findings stimulate further research to dissect different roles played by tissue inflammation in clinical settings, so we can utilize the positive effects and control the negative effects of tissue inflammation," said Lan Zhou, M.D., Ph.D., a researcher involved in the work from the Neuroinflammation Research Center/Department of Neurosciences/Lerner Research Institute at the Cleveland Clinic in Ohio.

Zhou and colleagues found that the presence of inflammatory cells (macrophages) in acute muscle injury produce a high level of a growth factor called insulin-like growth factor-1 (IGF-1) which significantly increases the rate of muscle regeneration. The research report shows that muscle inflammatory cells produce the highest levels of IGF-1, which improves muscle injury repair. To reach this conclusion, the researchers studied two groups of mice. The first group of mice was genetically altered so they could not mount inflammatory responses to acute injury. The second group of mice was normal. Each group experienced muscle injury induced by barium chloride. The muscle injury in the first group of mice did not heal, but in the second group, their bodies repaired the injury. Further analysis showed that macrophages within injured muscles in the second group of mice produced a high level of IGF-1, leading to significantly improved muscle repair.

"For wounds to heal we need controlled inflammation, not too much, and not too little," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal, "It's been known for a long time that excess anti-inflammatory medication, such as cortisone, slows wound healing. This study goes a long way to telling us why: insulin-like growth factor and other materials released by inflammatory cells helps wound to heal."

Posted: Sat Feb 26, 2011 10:19 am
by stuward
It's surprising to me why this would be considered surprising. It sounds like common sense to me. It underscores to me that you need to address the reason for the inflammation and not the inflammation directly. Inflammation is your bodies way of dealing with the problem, not the problem itself.

Re: Inflamation/IGF-1 For Wound Healing

Posted: Thu Nov 03, 2011 10:41 am
by Oscar_Actuary
hope you enjoyed your stay.

Re: Inflamation/IGF-1 For Wound Healing

Posted: Thu Nov 03, 2011 10:49 pm
by Jungledoc
I suspect that it was only the journalist who called it surprising. I'm sure that this is good new data on IGF, but the general idea that healing and inflammation are interrelated processes is not. When writers report things like this, they try to make it sound more revolutionary than it might really be.